Christina Applegate Says Her Multiple Sclerosis Diagnosis Was Wrong

Christina Applegate was diagnosed with multiple sclerosis in 2021, according to Deadline Hollywood. In the years that followed, she became an advocate for people coping with the disease.

That diagnosis had provided a name for her health struggles. Now, Applegate says it was wrong, without bringing an improvement in how she feels, The Hollywood Reporter reported.

On October 20, 2026, Applegate announced that she had been misdiagnosed with multiple sclerosis, according to NBC News.

She shared the news on her podcast, MeSsy. Consequence of Sound reported that the disclosure came in a two-part installment of the show.

Applegate stressed that the change in diagnosis had not made her better. "You don't get misdiagnosed and then all of a sudden, I'm better. I haven't gotten better," she said, according to The Hollywood Reporter.

Applegate said she was still in a state of "shock" after learning she does not have multiple sclerosis, Express & Star reported. She described herself as "back at square one," according to The Hill.

The distinction is central to her announcement: she says the diagnosis was incorrect, not that her health problems have resolved. The supplied coverage does not identify another diagnosis or set out her next medical steps.